GABA, “aka: gama-aminobutyric acid,” is the most abundant neurotransmitter in the brain that helps inhibit over-excitement. When you are irritable, cranky, anxious, or experience feelings of nervousness over an extended period of time, your body physically reacts.
- * Anxiety, irritability, nervousness
- * Unexplained Aches & Pains
- * Poor Sleep
- * Lack Of Concentration
- * Lightheadedness
- * Upset Stomach
Not only is it important to take care of your physical health, but your mental health, too. This is often referred to as the mind/body connection!
Proper levels of GABA promote clarity, calmness, & an overall sense of well-being.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested Dosage ~ Nervous Irritablity & Restlessness
Take 2 capsules twice daily – not exceeding 6 capsules per day, or as directed by a health care professional.
Suggested Dosage ~ For Relief Of Occassional Sleeplessness
Take 2 capsules 15-30 minutes right before bedtime or as directed by a health care professional.
Ingredients in GABA COMPLEX (GABA Calm):
Also known as “4-Amino-3-Phenylbutyric Acid,” Phenibut is a non-prescription pharmaceutical that is actually a GABA molecule with the addition of a phenyl group. Russian researchers discovered that by changing GABA into 4-Amino-3-Phenylbutyric Acid, it was able to cross more easily into the nervous system & across the blood-brain barrier. Since it is a GABA, an inhibitory neurotransmitter, derivative, Phenibut increases GABA levels.
The most widely distributed neurotransmitter in the brain, GABA is involved in 40-50% of all brain synapses. The basal ganglia, a complex group of nerve control centers in each 1/2 of the brain, is where GABA is the most concentrated. The basal ganglia is involved in cognition, movement coordination & voluntary movement. GABA also resides in the hypothalamus, hippocampus, cortex,
amygdala, & thalamus.
As stated before, it is an inhibitory neurotransmitter, which means it blocks nerve impulses. GABA is like a speed bump for nerve transmissions – slowing things down. As the brain becomes stimulated, it can quickly make a mountain out of a mole hill & run out of control. Nerve cells are firing too often & too easily. GABA hinders the transmission of nerve impulses… calming the storm.
GABA is produced during the citric acid cycle, also known as the “Krebs Cycle.” During this cycle, glucose, proteins, & fats are converted into the form of energy known as ATP – adenosine triphosphate. ATP is used by living cells to synthesize proteins from amino acids & replicate DNA – deoxyribonucleic acid.
GABA influences the flow of Chloride ions into the neurons & Potassium ions out of the neurons. More Chloride ions are allowed to enter the brain cell by the GABA receptor. This step increases the negative electrical charge on the inside of the neuron, while on the outside, the Potassium increases the positive charge. This makes it more difficult for the neuron to fire. Thus, corresponding neurons are not triggered & you aren’t sent into a frenzied state. You are calm, cool, & collected, even though under stress.
The body readily synthesizes L-Glutamine, which is the 3rd most abundant amino acid in the blood & brain. L-Glutamine is found in the highest concentrations of the skeletal muscle, brain liver, & stomach. In fact, the skeletal muscle contains 60% of the L-Glutamine stores. When the body is under metabolic stress, L-Glutamine is released into the bloodstream to go to the tissues in need.
L-Glutamine is fuel for the body & brain! In fact, blood sugar, aka: glucose, is the only other compound that the brain can use for energy. L-Glutamine supports focus, concentration, clarity, sense of well-being, & alertness.
This little amino acid is a huge supporter of the immune system. It supports the healthy proliferation of white cells. Recall that white cells are our body’s defenders, fighting off foreign particles & invading microorganisms. The GI tract actually uses the greatest amount of L-Glutamine in the body. Out of all of the organs in the body, the small intestine absorbs the most! L-Glutamine supports the integrity of the intestinal lining.
Taurine is found throughout the body & like the other amino acids, is involved in a multitude of functions. It is found in higher concentrations in the heart muscle, olfactory bulb, CNS, & brain – specifically the hippocampus & pineal gland. In the brain, it is the 2nd most important inhibitory neurotransmitter – next to GABA.
The hippocampus is a horsehoe shaped paired structure that is the part of the brain involved in memory forming, organizing, & storing. Ever come across a smell or hear a noise that suddenly triggers a memory from your past? You have just experienced the the work of the hippocampus.
The pine cone shaped gland connecting the endocrine system with the nervous system is the pineal gland. This structure is located between the cerebral hemispheres of the brain & is involved in several body functions. The pineal gland produces several hormones, primarily melatonin.
Melatonin helps control your sleep-wake cycles. Your body has an internal clock that controls when you are awake & when you are asleep. This internal clock controls your melatonin levels. Normally, melatonin levels start to rise in the mid to late evening & remain high most of the night, decreasing as morning grows near. However, light (natural & artificial) affects the body’s production of melatonin & so does age. As we age, the natural melatonin levels tend to drop. In fact, some adults make very little to no melatonin at all.
Taurine supports normal brain development. The concentration of Taurine is 4 times higher in the developing brain versus an adult brain. Like GABA (& Glycine), Taurine acts as an inhibitory neurotransmitter in the brain. In the heart, it is the most concentrated amino acid, as it is involved in the heart’s muscular contractility & rhythms. It is necessary for the formation of one of the bile acids & supports the proper functioning of the gall bladder.
“Feel good?” Say thank you to Serotonin! Serotonin is is a hormone that is credited with maintaining that “happy feeling.” It helps transmit messages along the nerve pathways. Serotonin plays a role in mood, digestion, sleep & sexuality. This hormone produces a relaxed, calm, secure, mellow feeling.
Serotonin levels fluctuate throughout the day. Caffeine, nicotine alcohol, & antidepressants can deplete your levels of serotonin, as well as lack of sunlight. However, exercise can increase both serotonin (& dopamine) levels in the blood!
This amino acid has the simplest structure of all the amino acids & resembles glucose & glycogen. It is the 3rd major inhibitory neurotransmitter in the brain & readily passes through the blood-brain barrier. Glycine is used by the body to form DNA, collagen, phospholipids, & for the release of energy.
Glycine plays a role in the metabolism of protein, peptides, & bile salts. This amino acid supports heavy metal detoxification, as well as decreases the craving for sugar. In the brain, Glycine also helps to “slow down” stress related messages full of angst & anxiousness.
L-Theanine promotes the production of alpha waves in the brain & influences GABA production. Plus, L-Theanine plays a role in the release of dopamine & serotonin.
Alpha brain waves are the dominant waves in your brain when your body & mind are relaxed. They are often considered to be the healthiest brain wave range. The brain is less vulnerable to stress side effects, if alpha brain waves are present.
We have already discussed the importance of GABA & serotonin. But what about dopamine? Dopamine is needed to produce epinephrine & norepinephrine, which are hormones that are involved in the “fight-or-flight” response. This neurotransmitter, which is produced by the hypothalamus, also causes feelings of pleasure (ie: from food or sex) & is required to maintain healthy cognitive function – concentration, memory, & problem solving.
What an amazing vitamin! Affecting both mental & physical health, Vitamin B6 is involved in more
bodily functions than almost any other single nutrient. This vitamin is involved in nerve function & also has a part in the synthesis of red blood cells, neurotransmitters, & the hormones, serotonin, norepinephrine, & melatonin. It plays a role in the absorption of fats & proteins, activates several enzymes, supports a healthy immune system, a healthy circulatory system, & is used mainly by the body to process amino acids.
Because of Vitamin B6, amino acids can be synthesized, like Glutamine from Glutamate & Taurine from Cysteine. This vitamin also helps break down amino acids so that they can be more readily absorbed by the body. Vitamin B6 is very important to the metabolism of amino acids within the intestines. It is important to note that as you increase your energy expenditure, such as exercise, you will need to increase your Vitamin B6.
Norepinephrine, “aka: noradrenaline,” is produced in the core portion of the adrenal glands – adrenal medula. It is classified both as a hormone & a neurotransmitter. Stress, either physical or psychological will trigger its release. Norepinephrine will activate the body’s “fight-or-flight response” & increases attention & reaction time.