SIBO is a rising area of focus in functional medicine because as microorganism levels in the small intestine increase, so does microbial activity, such as fermentation. When fermentation increases in the small intestine, even healthy diets can cause gas, bloating, and intolerance to certain foods and probiotics. Many gastrointestinal complaints have been attributed to sensitivity, but the culprit may be an imbalance in the small intestinal ecosystem due to overuse of antibiotics and a reduction in key GI-supporting factors like short-chain fatty acids, proper pH, polyphenols and ber from the diet, and healthy intestinal motility.
Restoring the Terrain
Bacillus spores are a novel type of probiotic that remain dormant until they reach favorable environments in the gastrointestinal tract. In their active form, spores have a long life cycle and slowly colonize the distal GI tract. Here, they perform quorum sensing, a biological mechanism that allows Bacillus species to sense their environment and reestablish microbial balance when unwanted species are present. Bacillus spores produce necessary nutrients like short-chain fatty acids, vitamins and antioxidants, in addition to compounds necessary for regulating microbial balance in the gut. This intuitive ability to adjust environmental factors to re-establish homeostasis is important in small intestinal bacterial overgrowth because re-establishing terrain can be extremely challenging.
Dual-Action Solution For SIBO
1. Push-Microbial Diversity without Disruption
- Activated Bacillus strains use quorum sensing in the small intestine to gently “push” non-resident species back into the large intestine and restore proper microbial diversity and balance.
2. PULL-Increase mucosal immunity and bind harmful toxins
- Serum-derived bovine immunoglobulins (SBI) bind and “pull” the remaining lipopolysaccharides (LPS), gram-negative bacterial cell components, and other toxins from the environment for elimination.
Bacillus species use quorum sensing to group together, communicate, and produce active compounds that deter unwanted organisms. This intelligent networking triggers the production of key enzymes that inhibit the growth of undesirable bacteria. This results in bacterial breakdown, which can expose the gut to toxic compounds.
Concentrated immunoglobulins have broad-spectrum capacity to bind toxins and cell components released when bacteria are broken down. This neutralizes and protects the GI tract while supporting healthy microbialblance.
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